Gene Cloning and DNA Analysis: An Introduction

Book Description

Known world-wide as the standard introductory text to this important and exciting area, the fifth edition of Gene Cloning and DNA Analysis addresses new and growing areas of research whilst retaining the philosophy of the previous editions. Assuming the reader has little prior knowledge of the subject, its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented two-colour illustrations.In addition to a number of informative changes to the text throughout the book, the final four chapters have been significantly updated and extended to reflect the striking advances made in recent years in the applications of gene cloning and DNA analysis in biotechnology.

Customer Reviews:

clearly written undergraduate text.......2006-11-30

As an introductory text on its subject, the book is well written. With copious diagrams that are easy to understand and that illustrate key ideas. A merit of the book is the clarity of the textual exposition, reinforced by those diagrams.

The text is also quite up to date in this fast changing field. With the good coverage of many topics. Including the seminal Polymerase Chain Reaction, that is the basis of so much else. You can see that genomics/biotechnology is now a practical and quantitative science. With plenty remaining to be understood, to be sure. But the book shows that we now have powerful tools to experiment with, to reduce our ignorance.

Up to date and still very readable.......2006-04-12

This book has become the standard introductory text at the undergraduate level for students in the first or second year of college and as an introductory book for researchers whose specialty lies in other areas but needing to know more about the subject. While an introductory text, it does presume that you are approaching the subject with at least some background in biology. If nothing else, you need to know what a gene is and have some idea about why you would want to clone it.

This basic book has been around for about twenty years. The twenty years since then have seen tremendous advances in the techniques and science as they now exist. This is the fifth edition of the book and it is as up to date as any printed book can be.

Since the book was written the public awareness of genetically altered plants has increased tremendously. A major goal of this new edition is to present to the student the true facts about genetically modified agricultural products. The final chapter on Forensic science and Archaeology is most fascinating as it provides a non technical look at DNA analysis in criminal acts and in the tracing of the human species.

Highly recommended.

A Good Book for Introductory Courses in Molecular Biology.......2004-12-31

I am a science student Studying Biochemistry and Molecular Biology. I used this book as a reference book for an Introduction to Genetic Engineering course. It was a great help for me. The book outlines the basic principles and methods in many aspects of Molecular Biology and Genetic Engineering in the simplest of ways. The book is easy to understand even to people with no big background in Molecular Biology as it explains everything from zero. It is a great book for introductory courses or as a quick reference for the basic ideas of some techniques and advances in the field. It does not give a lot of detail and explanation that is usually required from university students, such as myself, so more in-depth references are certainley required. However, as a joyful read for those interested in the field, or simply as a quick revision of the basics before your final exam, this book works wonders! Trust me... I got a straight A (99% on my final) :) All in all, it's a good book!

A Versatile, Accessible Introduction.......2001-10-14

I came away very impressed from Dr. Brown's latest edition. The book is extremely readable but does not dumb down the material. I'm taking an upper-level molecular genetics lab and am doing independent work in genetics, and this book is a great reference. However, I think that this book would be pretty easy for someone with introductory level biology--heck, I think some AP Biology high school teachers may be able to use this text for their classes.

Book Description

On the forefront of modern scientific innovation, Cloning, Gene Expression and Protein Purification: Experimental Procedures and Process Rationale effectively doubles as a laboratory manual for students and a reference book for professional researchers. Designed for advanced undergraduate and beginning graduate students in molecular biology, this unique combination lecture/laboratory resource presents detailed protocols for the multi-step process involved in isolating a gene, cloning and characterizing it, expressing its encoded protein, and purifying and characterizing the protein's basic physical properties. This manageable volume includes both theoretical background and practical procedures and is structured around twenty experiments that demonstrate how to prepare, manipulate, and analyze plasmids, produce fusion proteins in bacteria, and purify these proteins based on unique chemical properties or substrate affinities. The book describes advanced topics such as the use of antibodies and the techniques developed to transform their structures, as well as combinatorial approaches designed to manipulate the structure and functions of proteins and nucleic acids. Supplemental literature provides a variety of theoretical explanations encouraging a more intuitive understanding of the experimental mechanisms and behaviors of the chemical participants, while also giving students the tools needed to become "capable proactive researchers." Features: DT Emphasizes electrophoresis, Southern and Western blotting, and combinatorial techniques DT Defines clear reaction mechanisms; stipulates the functions of reagents; and helps students think about the precise consequences of solution and procedural manipulations DT Discusses fluorophores, and solvent effects on protein structure DT Characterizes plasmids, cDNAs, and antibody probes (available from ATCC) in research literature DT Includes carefully selected primary source research literature and articles from current vendor literature DT Contains a glossary of unfamiliar phrases and jargon; important summary statements and conclusions are italicized DT Provides an alphabetized list of common reagents for rapid reference DT Offers an extensive index of concepts and terms DT Categorizes helpful and distinctive information into five types of supplemental literature: Innovation/ Insight, Theory/Principle, Process Rationale, Vendor Literature, and Alternative Approaches

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Gene Cloning
Julia Lodge
Manufacturer: Taylor & Francis
ProductGroup: Book
Binding: Paperback

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ASIN: 0748765344

Book Description

Cloning genes has become such a routine part of molecular biology, and the approaches to it so many and diverse, undergraduates can easily be overwhelmed. Gene Cloning is designed to give the undergraduate a broad overview of the subject, guiding the student through the basic elements involved and their utility, and further through the interpretation of results and datasets. Having understood the basic processes, the reader is introduced to some of the most common uses of gene cloning, from applications with more research-oriented goals to practical applications in biotechnology in medicine. Clearly presented in two-colour text, Gene Cloning is essential reading for undergraduates in the molecular life sciences.

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ABCs of Gene Cloning
Dominic W.S. Wong
Manufacturer: Springer
ProductGroup: Book
Binding: Paperback

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Book Description

Clear and concise, this easy-to-use text offers an introductory course on the language of gene cloning, covering microbial, plant, and animal systems. The essential concepts in biology relevant to the understanding of gene cloning are presented in a well-organized and accessible manner. Consistent with its introductory nature, the book begins by outlining the basic principles of biology and aspects of genetics relevant to the concepts of gene cloning. The next section explores the common techniques and approaches used in gene cloning. The author then discusses various applications in agriculture and food, and in medicine and related areas. The practical uses of gene cloning are extensively illustrated, with specific examples from the literature to demonstrate how gene cloning is conducted utilizing the concepts developed in previous sections. Review questions at the end of each chapter provide self-testing, allowing the reader to assess their understanding of the materials. With more than 90 illustrations, The ABCs of Gene Cloning is an invaluable book for nonscientists as well as scientists with little background knowledge in gene cloning. It provides a wealth of information for anyone with a desire to gain some proficiency in reading and speaking the language of gene cloning. The book covers the essential concepts of gene cloning, paying special attention to explaining jargon in simple, easy-to-understand terms. A unique feature of this book is the inclusion of sample applications of gene cloning in food science, nutrition, and biomedicine, making it a much-needed reference for individuals in these fields who lack formal training in this increasing important area. End-of-chapter exercises and reading assignments are presented to facilitate self study.

Gene Delivery to Mammalian Cells, Vol. 2: Viral Gene Transfer Techniques (Methods in Molecular Biology (Cloth))

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Gene Delivery to Mammalian Cells, Vol. 2: Viral Gene Transfer Techniques (Methods in Molecular Biology (Cloth))
William C. Heiser
Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588290956

Book Description

Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors. An accompanying volume, Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics.

Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology (Milestones in Drug Therapy)

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Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology (Milestones in Drug Therapy)

Manufacturer: Birkhäuser Basel
ProductGroup: Book
Binding: Paperback

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ASIN: 3764375426

Book Description

This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia will be covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators. This softcover volume is an unchanged second printing of the hardcover edition published in 2003.

Baa!: The Most Interesting Book You'll Ever Read about Genes and Cloning (Mysterious You)

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Baa!: The Most Interesting Book You'll Ever Read about Genes and Cloning (Mysterious You)
Cynthia Nicolson
Manufacturer: Kids Can Press, Ltd.
ProductGroup: Book
Binding: Paperback

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ASIN: 1550748866

Book Description

The Mysterious You series explores the mysteries of the human body using an exciting mix of thoroughly researched factual information, amazing anecdotes and surprising try-it activities. In Baa!, kids unravel the mysteries of genes and see how traits like dimples and hair color are passed down through their family tree. They can then explore the secrets of cloning -- what it is and what changes it may bring in the future. Kids can learn about * natural selection * genetic mutations * DNA and forensics * gene mapping * cloning in nature and in the lab * future predictions With simple language and kid-friendly examples, Baa! helps demystify an intriguing, but often difficult-to-grasp, subject in a way that kids can understand.

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Gene Machines (Enjoy Your Cells)
Frank Balkwill
Manufacturer: Cold Spring Harbor Laboratory Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0879696117

Book Description

Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA.

It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time—and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development…here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations—no expert required!

Book Description

Will has been trained since birth to promote The Goodness, his father's program to maintain order in the Dominion. Now that he is sixteen,Will is sent to witness firsthand the synthetic production of food and humans, and the euthanasia program that the authorities call Compassionate Removal.The more Will sees, the more he questions his role. When Will discovers the shocking truth about himself—that he is the clone of a twentieth-century despot—he realizes that the future of the world lies in his hands.

This suspenseful, innovative novel raises fascinating questions about whether our behavior is determined by DNA, upbringing, or a higher power.

Customer Reviews:

Thrilling Futuristic Adventure..........2005-12-19

Having been my first novel written by Sonia Levitin, I was not quite sure what to expect of this novel. From the first few pages, however, my imagination was captivated and remained so throughout the course of the novel. Weaving a suspenseful tale set a few hundred years from now, Levitin tells the story of one young man, Will, and his journey towards self-understanding and the realization that perhaps his world is not the best of all possible worlds. After a catastrophic cataclysm, "The Collapse," a new society dominated by one supreme ruler, Hayli, forces edicts that suppress society. Will, being the supposed son of Hayli, is forced to compete with his twin brother, Berk, for control over the government. As the novel progresses, and Will encounters a young woman named Leora, he discovers facts that question the source of his existence and the falsified truth that he has been forced to accept. This futuristic novel, not only provides a thrilling story-line, but raises questions about ethics in our current society. I would reccommend this novel to just about anyone searching for an entertaining read that also provokes thought.

A Terrible Beauty is Born: Clones, Genes and the Future of Mankind (Science Spectra Book Series)

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A Terrible Beauty is Born: Clones, Genes and the Future of Mankind (Science Spectra Book Series)
Brenda Curran
Manufacturer: CRC
ProductGroup: Book
Binding: Paperback

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Book Description

Genetics and its related technologies are revolutionizing the world. The media is regularly dominated by controversy over the latest genetically modified (GM) food, human gene therapy or cancer chip technology. Maverick scientists are in the process of cloning humans, and the human genome sequence is available on the Internet. Fifty years ago we did not know what a gene was; today the awesome power of genetics is being released on an unsuspecting public, and with it a whole series of ethical dilemmas undreamt of even ten years ago. The question now has become not "can we?" but "should we?" By demystifying genetic engineering and exploring the basic biology of the living world, A Terrible Beauty is Born explains how clones and cloning technology are in many ways extensions of processes that occur constantly in nature. Used wisely these processes have the potential to bring enormous benefits; abused, they carry with them potential dangers that we ignore at our peril.

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